Scientist – In Vitro & In Vivo Biology
\nAbout the Company
\nInstitutionally backed biotech focused on neuroscience and the development of novel therapeutics.
\nPosition Summary
\nWe are seeking a highly motivated Scientist to join our research team and contribute to the
\nadvancement of therapeutic discovery programs, with an emphasis on neuroscience and
\nneurological disease. This is a hands-on position for an early-career scientist with a strong
\nexperimental background spanning in vitro and in vivo biology.
\nThe Scientist will design and execute experiments to investigate disease-relevant biology,
\ntherapeutic mechanisms, and pharmacological activity. As a member of a small, multidisciplinary
\nteam, this individual will have broad scientific exposure and the opportunity to develop increasing
\nownership of research programs and contribute to scientific strategy.
\nThis position is particularly well suited for candidates who enjoys experimental work and is interested
\nin developing into an independent drug discovery scientist.
\nKey Responsibilities
\n• Design, execute, analyze, and troubleshoot in vitro and in vivo studies supporting discovery and
\npreclinical research programs.
\n• Develop and optimize cellular assays and disease-relevant experimental models to characterize
\nbiological mechanisms and therapeutic activity.
\n• Conduct in vivo pharmacology and proof-of-concept studies, including dosing, sample
\ncollection, tissue harvesting, and downstream analysis.
\n• Perform quantitative molecular, cellular, and biochemical analyses of cells, tissues, and other
\nbiological samples.
\n• Integrate in vitro, ex vivo, and in vivo findings to characterize biological activity and inform
\nprogram decisions.
\n• Apply rigorous experimental design, appropriate controls, and quantitative analysis to generate
\nhigh-quality, reproducible data.
\n• Troubleshoot experimental methods and recommend follow-up studies based on emerging
\nresults.
\n• Maintain accurate experimental records and clearly communicate findings to the broader
\nresearch team.
\n• Collaborate across disciplines and contribute to research activities as program needs evolve.
\n• Develop new assays, models, and research capabilities.
\n• Support studies conducted with CROs and external collaborators.
\n• With increasing experience, contribute to experimental strategy, program planning, and scientific
\ndecision-making.
\n3210 Merryfield
\nSan Diego, CA 9212
\nDiaxis Therapeutics,
\nQualifications
\n• PhD in biology, pharmacology, neuroscience, molecular or cellular biology, biochemistry,
\nbiomedical sciences, or a related discipline with 0+ years of industry experience. Or a
\nBachelor’s or Masters in biology, pharmacology, neuroscience, molecular or cellular biology,
\nbiochemistry, biomedical sciences, or a related discipline with 5+ years of industry experience in
\na related field.
\n• Strong hands-on experimental background in cellular and molecular biology, pharmacology, or a
\nrelated field.
\n• Experience with both in vitro experimental systems and in vivo animal studies.
\n• Experience with mammalian cell culture, primary cells, or other physiologically relevant cellular
\nsystems.
\n• Experience conducting in vivo studies, including animal handling, dosing, sample collection,
\ntissue harvesting, and/or tissue processing.
\n• Strong understanding of experimental design, controls, quantitative analysis, and biological
\ninterpretation.
\n• Ability to independently execute and troubleshoot experiments.
\n• Strong organizational, problem-solving, and scientific communication skills.
\n• Ability to work effectively in a collaborative, fast-paced research environment.
\nPreferred Qualifications
\n• Background in neuroscience, neurobiology, neuropharmacology, or neurological disease biology
\nis preferred but not required.
\n• Experience with primary neurons, iPSC-derived cells, brain tissue, or other disease-relevant
\ncellular models.
\n• Experience with in vivo models of neurological disease or CNS pharmacology.
\n• Experience supporting therapeutic discovery or translational research programs.
\n• Experience with pharmacology, pharmacodynamics, biomarkers, or mechanism-of-action
\nstudies.
\n• Experience with quantitative protein assays, including MSD (Meso Scale Discovery),
\nAlphaLISA, ELISA, and/or Western blotting.
\n• Experience with quantitative RNA assays, including QuantiGene, dPCR and/or qPCR.
\n• Experience with ex vivo analysis of biological samples or tissues.
\n• Familiarity with CNS drug delivery, exposure, or PK/PD relationships.
\n• Biotechnology or pharmaceutical industry experience is beneficial but not required.
\nAttributes for Success
\nThe successful candidate will be scientifically curious, technically strong, and motivated to remain
\nclosely engaged in experimental research. The individual should be comfortable learning new areas
\nof biology, working across in vitro and in vivo systems, and adapting experimental approaches as
\nnew data emerge.
\nWe value individuals who take ownership of their work, communicate results clearly, and balance
\nscientific rigor with the practical needs of advancing research programs. This role provides an
\nopportunity to develop increasing independence in experimental design, data interpretation, and
\nscientific decision-making while gaining broad experience in drug discovery within an early-stage
\nbiotechnology company.
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